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0.5 mg dutasteride / 0.4mg tamsulosin hydrochloride

Product Overview

Combodart Pack & Bottle

Combodart - What is it?

  • Combodart (dutasteride 0.5mg/ tamsulosin hydrochloride 0.4mg) is the first single capsule, fixed-dose combination therapy to be approved in Europe for the treatment of moderate-to-severe symptoms of benign prostatic hyperplasia (BPH) and is now available for prescription.
  • It is also indicated for the reduction in the risk of acute urinary retention (AUR) and BPH-related surgery. [1 ]
  • Combodart is the first treatment available in Ireland that combines the benefits of two existing treatments for BPH, which have complementary modes of action. [1 ]
  • This dual mode of action therapy uses a 5- alpha reductase inhibitor (5ARI), dutasteride, to reduce the size of the prostate and an alpha-blocker, tamsulosin, to relax the smooth muscle in the prostate and bladder neck. Both actions improve urinary flow. [2 ]

How to take Combodart

  • The recommended dose of Combodart is one capsule (0.5mg/ 0.4 mg) taken orally approximately 30 minutes after the same meal each day.
  • The capsules should be swallowed whole and not chewed or opened.
  • Where appropriate, Combodart may be used ti substitute concomitant dutasteride and tamsulosin in existing dual therapy to simplify treatment.
  • Where clinically appropriate, direct change from dutasteride or tamsulosin monotherapy to Combodart may be considered.

Combodart - How does it work?

Combodart is a fixed-dose combination therapy of two drugs: dutasteride and tamsulosin. there drugs have complimentary mechanisms of action that rapidly improve symptoms, urinary flow and reduce the risk of acute urinary retention (AUR) and the need for BPH-related surgery.

  • Dutasteride belongs to a group of medicines  called 5-alpha-reductase inhibitors. [1 ] [2 ]
  • Tamsulosin belongs to a group of medicines called alpha blockers.
  • Dutasteride lowers production of dihydrotestosterone (DHT), the androgen primarily responsible for prostate growth by inhibiting type 1 and type 2 5-alpha-reductase.
  • Suppression of DHT helps to shrink the prostate and relieve urinary symptoms.
  • The risks of acute urinary retention and the need for surgery are also reduced. [2 ]  
  • Tamsulosin acts by relaxing the muscles in your prostate gland, making it easier to pass urine and rapidly improving the symptoms. [2 ]

For further information on Combodart please see the Combodart Summary of Product Characteristics (SPC ). [1 ]


  1. Combodart Summary of Product Characteristics
  2. de la Rosette J, Alivizatos G, Madersbacher S et al. Guidelines on Benign Prostatic Hyperplasia. European Association of Urology 2008
Combodart™ is a trade mark of the GlaxoSmithKline group of companies.

M.O. : Last updated 26 April 2012: IE/DUTT/0016/12

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